Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis Running title: Döring et al.; pDCs in atherosclerosis
نویسندگان
چکیده
Inst for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich; Inst for Biomedical Engineering, Dept of Cell Biology, RWTH Aachen University, Aachen; Rudolf Virchow-Center/ DFG-Rsrch Ctr for Experimental Medicine, University of Würzburg, Würzburg, Germany; Cardiovascular Research Inst Maastricht, Maastricht University, Maastricht, The Netherlands; Dept of Vascular Surgery, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany; Ctr for Molecular Medicine (CeMM) of the Austrian Academy of Sciences & Dept of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; Munich Heart Alliance, Munich, Germany
منابع مشابه
Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.
BACKGROUND Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil extracellular traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disea...
متن کاملPlasmacytoid Dendritic Cells in Atherosclerosis
Atherosclerosis, a chronic inflammatory disease of the vessel wall and the underlying cause of cardiovascular disease, is initiated and maintained by innate and adaptive immunity. Accumulating evidence suggests an important contribution of autoimmune responses to this disease. Plasmacytoid dendritic cells (pDCs), a specialized cell type known to produce large amounts of type I interferons (IFNs...
متن کاملPlasmacytoid dendritic cells in angiolymphoid hyperplasia with eosinophilia
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is characterized by irregularly-shaped blood vessels with an inflammatory infiltrate. While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin upon injury and during several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adapti...
متن کاملCommentary: Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells
Plasmacytoid dendritic cells (pDCs) are unique bone-marrow-derived cells that produce large amounts of type I interferon in response to microbial stimulation. Furthermore, pDCs also promote T cell tolerance in sterile-inflammation conditions. However, the immunomodulatory role of aortic pDCs in atherosclerosis has been poorly understood. Here, we identified functional mouse and human pDCs in th...
متن کاملPlasmacytoid Dendritic Cells: From Heart to Vessels
Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via t...
متن کامل